Health Care

Spyre Therapeutics, Inc. (SYRE) options and signal

Figures as of 28 Sep 2026

SYRE is Spyre Therapeutics, Inc., a Health Care name the model ranks every trading day. The options figures are from the close on 28 Sep 2026. The model's figures are from 25 Sep 2026, one trading day behind the latest, as the Free plan shows them. Every model figure is paper trading.

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At a glance

Figure	Value	Date
IV rank	0 of 100	28 Sep
At the money IV	62.4%	28 Sep
Priced move to 16 Oct	12.8% down, 13.2% up	28 Sep
Call wall and put wall	90 and 85	28 Sep
Signal and the desk's view	No signal, view neutral	25 Sep
Last close	85.79	28 Sep
Next report	3 Nov 2026	28 Sep

Options Snapshot

SYRE's IV rank is 0 of 100 on 28 Sep 2026.

Figure	Value
IV rank	0 of 100
At the money IV	62.4%, near month, 18 days
Put/call ratio, open interest	1.89
Call open interest, strikes captured near the price	334 contracts
Put open interest, strikes captured near the price	630 contracts
Cost to trade at the money	Wide, 79.3% of the option's mid price

IV rank is where the at the money IV sits among SYRE's own weekly readings, 0 the lowest and 100 the highest.

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Priced Range

On 28 Sep 2026, SYRE options priced a move of 12.8 percent down and 13.2 percent up by 16 Oct 2026.

Expiry	Days	Down	Up	Range
16 Oct 2026	18	12.8%	13.2%	74.79 to 97.09
20 Nov 2026	53	23.7%	25.8%	65.49 to 107.89
18 Dec 2026	81	34.2%	35.3%	56.49 to 116.09
15 Jan 2027	109	60.6%	60.6%	33.79 to 137.79
19 Mar 2027	172	41.6%	41.6%	50.09 to 121.49

The range is one standard deviation either side of the close of 85.79, as the option prices imply it.

A priced move restates option prices at the close and says nothing certain about where the price goes.

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Gamma Map

On 28 Sep 2026, SYRE's call wall is the 90 strike and its put wall is the 85 strike.

Figure	Value
Call wall, most open call gamma	90
Put wall, most open put gamma	85
Net dollar gamma, calls minus puts	minus $68,862
Total dollar gamma, both sides	$137,490
Close	85.79

Dollar gamma is stated for a one percent move in the price.

Net is calls minus puts under the standard convention, not a record of who holds the contracts.

Net gamma changes sign at 6 strikes, so no single flip strike is named.

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Volatility History

On 28 Sep 2026, SYRE's at the money IV is 62.4 percent against 20 day realized volatility of 31.5 percent.

Figure	Value
At the money IV	62.4%
Realized volatility, 20 trading days	31.5%
Realized volatility, 60 trading days	55.7%
IV against its own weekly record	Low, in the bottom fifth
Weekly readings on record	98, from 26 Apr 2024
Weeks the price moved more than the one week priced move	10.3% of 97 weeks

Realized volatility is worked out from the daily closes the desk holds, not from the option chain.

From the option chain at the close on 28 Sep 2026. Current on every plan.

Open Volatility History in RingMaster The Volatility History guide

Volatility Weather

On 28 Sep 2026, SYRE's at the money IV runs from 62.4 percent at 18 days to 60.6 percent at 172 days.

Days to expiry	At the money IV
18	62.4%
53	65.3%
81	72.4%
109	111.0%
172	60.6%

Near expiries price more volatility than far ones, an inverted term structure.

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Volatility Smile

On 28 Sep 2026, at the 53 day expiry, SYRE's IV ten percent below the price sits 0.4 points above at the money IV.

Strike area	Implied volatility	Against at the money
10% below the price	65.6%	+0.4 points
At the money	65.3%	0.0 points
10% above the price	62.8%	-2.5 points

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Volatility Surface

On 28 Sep 2026, SYRE's surface spans 5 expiries out to 172 days, with IV from 57.7 to 204.8 percent near the price.

Figure	Value
Expiries captured	5
Nearest expiry	16 Oct 2026, 18 days
Farthest expiry	19 Mar 2027, 172 days
Points within 10% of the price, 7 days out or more	11
Lowest IV among them	57.7%
Highest IV among them	204.8%

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Expiry Ladder

On 28 Sep 2026, SYRE has 5 captured expiries, from 16 Oct 2026 to 19 Mar 2027.

Expiry	Days	At the money IV	Call open interest	Put open interest
16 Oct 2026	18	62.4%	66	497
20 Nov 2026	53	65.3%	78	38
18 Dec 2026	81	72.4%	103	48
15 Jan 2027	109	111.0%	14	4
19 Mar 2027	172	60.6%	73	43

Open interest is summed over the strikes captured near the price on each expiry.

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Strike Table

On 28 Sep 2026, SYRE's largest open interest sits at the 85 strike, with 242 contracts across the captured expiries.

Strike	Call open interest	Put open interest	Total
85	17	225	242
70	6	176	182
90	79	30	109
100	67	33	100
95	23	59	82
80	20	46	66

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Since Yesterday

From 25 Sep 2026 to 28 Sep 2026, SYRE's at the money IV moved from 62.8 percent to 62.4 percent.

Figure	25 Sep	28 Sep	Change
At the money IV	62.8%	62.4%	-0.3 points
Open interest, strikes captured near the price	920	964	+44
Put/call ratio, open interest	1.84	1.89	+0.05

Open interest changes cannot identify buyers or sellers.

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Changed Hands

On 28 Sep 2026, 227 SYRE option contracts traded, 0.9 times its own recent average.

Figure	Value
Calls traded	126
Puts traded	101
Against its recent average	0.9 times
Busier than	4 of its last 18 trading days
Open interest, whole chain	990 contracts
Volume to open interest	0.23
Unusual volume flag	No

Traded volume and open interest are shown side by side and never combined. Open interest changes cannot identify buyers or sellers.

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Positioning Replay

The replay holds 19 trading days of SYRE's option positioning, from 1 Sep 2026 to 28 Sep 2026.

Date	Close	Net dollar gamma	Top call strike	Top put strike
1 Sep 2026	88.50	minus $331,170	95	105
21 Sep 2026	92.03	minus $209	90	95
28 Sep 2026	85.79	minus $68,862	90	85

Each frame restates one nightly capture. Net is calls minus puts, a convention, not who holds the contracts.

From the option chain at the close on 28 Sep 2026. Current on every plan.

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Read-out

On 25 Sep 2026 the desk's view of SYRE was neutral, paper trading.

Figure	Value
Side	Neutral at 45 trading days, no signal
Level above the close	91.41, the swing high of 11 Sep 2026
Level below the close	84.00, the swing low of 2 Sep 2026
Strategy family	Long straddle (buy a call and a put at the same strike)
Price target	None. The desk has no price model.

The levels are prices the shares turned at on the chart, with the date of each.

Paper trading. The model's figures from 25 Sep 2026, one trading day behind, as the Free plan shows them.

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Rank by Timeframe

On 25 Sep 2026 SYRE sat at the 58th percentile of the model's 45 trading day ranking, paper trading.

Timeframe	Percentile	Side
10 trading days	83 of 100	Bullish
20 trading days	57 of 100	Neutral
45 trading days	58 of 100	Neutral

100 is the top of the ranking. A name in the middle three fifths is neutral.

Paper trading. The model's figures from 25 Sep 2026, one trading day behind, as the Free plan shows them.

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Timeframe Agreement

On 25 Sep 2026 SYRE's near timeframes were bullish and its long timeframe was neutral, paper trading.

Group	Timeframes	Side	On that side
Near	10 day, 20 day	Bullish	1 of 2
Long	45 day	Neutral	0 of 1

Paper trading. The model's figures from 25 Sep 2026, one trading day behind, as the Free plan shows them.

Open Timeframe Agreement in RingMaster The Timeframe Agreement guide

Signal History

On 25 Sep 2026 SYRE had carried no signal for 4 trading days, paper trading.

Trading day	Signal	45 day percentile
25 Sep 2026	None	58 of 100
24 Sep 2026	None	40 of 100
23 Sep 2026	None	8 of 100
22 Sep 2026	None	7 of 100
21 Sep 2026	Bearish	2 of 100
18 Sep 2026	None	6 of 100
17 Sep 2026	None	9 of 100
16 Sep 2026	None	16 of 100

Paper trading. The model's figures from 25 Sep 2026, one trading day behind, as the Free plan shows them.

Open Signal History in RingMaster The Signal History guide

Sector Split

On 25 Sep 2026, 32 of 120 Health Care names were bullish and 52 were bearish, paper trading.

Sector	Names	Bullish	Bearish	Neutral
Health Care	120	32	52	36

Paper trading. The model's figures from 25 Sep 2026, one trading day behind, as the Free plan shows them.

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Price Chart

SYRE closed at 85.79 on 28 Sep 2026.

Figure	Value
Last close	85.79
Change over 5 trading days	-6.8%
Change over 21 trading days	-8.4%
Change over 63 trading days	-4.8%
Change over 252 trading days	+449.6%
52 week high	110.17
52 week low	15.49
20 day moving average	89.24
50 day moving average	96.82
200 day moving average	66.52
RSI, 14 days	36

Worked out from the desk's own daily bars, adjusted for share splits.

From the daily bars through 28 Sep 2026. Current on every plan.

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Earnings Radar

SYRE reports next on 3 Nov 2026, a date worked out from past quarters.

Figure	Value
Next report	3 Nov 2026, after the close
Date	Worked out from past quarters
Move after the report of 29 Jul 2026	+3.7%
Move after the report of 30 Apr 2026	-6.8%
Move after the report of 28 Jan 2026	+1.3%
Move after the report of 8 May 2025	+9.6%

Earnings calendar as of 28 Sep 2026. Current on every plan.

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Seasonality

In the 10 Septembers on record, SYRE's average change was plus 1.6 percent, and it rose in 60.0 percent of them.

Month	Average change	Middle change	Share of years up	Years
September	+1.6%	+1.1%	60.0%	10
October	+10.9%	-3.0%	40.0%	10
November	+0.5%	-3.0%	40.0%	10

Each figure is a month end to month end change in past years. A past month says nothing certain about the next one.

Monthly history through 28 Sep 2026. Current on every plan.

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Questions

What is SYRE's IV rank?: SYRE's IV rank is 0 of 100 on 28 Sep 2026.
What move are SYRE options pricing?: On 28 Sep 2026, SYRE options priced a move of 12.8 percent down and 13.2 percent up by 16 Oct 2026.
Where are SYRE's call wall and put wall?: On 28 Sep 2026, SYRE's call wall is the 90 strike and its put wall is the 85 strike.
What was the desk's latest view of SYRE on the Free plan?: On 25 Sep 2026 the desk's view of SYRE was neutral, paper trading.
When does SYRE report earnings next?: SYRE reports next on 3 Nov 2026, a date worked out from past quarters.

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